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Patints whhav dvlopd a sv action tZYLOPIM (allopuinol) should not b statd on th dug.

Hypuicmia may b pimay, as in gout, sconday tdisass such as acut and chonic lukmia, polycythmia va, multipl myloma, and psoiasis. It may occu with th us diutic agnts, duing nal dialysis, in th psnc nal damag, duing stavation ducing dits, and in th tatmnt noplastic disas wh apid solution tissu masss may occu. Asymptomatic hypuicmia is not an indication tatmnt with ZYLOPIM (s INDICATIONS ).

A luid intak suicint tyild a daily uinay output at last 2 lits and th maintnanc a nutal o, pably, slightly alkalin uin a dsiabl t(1) avoid th thotical possibility omation xanthin calculi und th inlunc thapy with ZYLOPIM (allopuinol) and (2) hlp pvnt nal pcipitation uats in patints civing concomitant uicosuic agnts.

Nhancd bon maow suppssion by cyclophosphamid and oth cytotoxic agnts has bn potd among patints with noplastic disas, xcpt lukmia, in th psnc ZYLOPIM (allopuinol) . Howv, in a wll-contolld study patints with lymphoma on combination thapy, ZYLOPIM (allopuinol) did not incas th maow toxicity patints tatd with cyclophos-phamid, doxoubicin, blomycin, pocabazin, and/mchlothamin.

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the action of allopurinol differs from that of uricosuric agents, which lower the serum uric acid level by increasing urinary excretion of uric acid.